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Restriction enzymes, modifying enzymes, buffering solutions, inhibitors, and substrates for use in clinical, research, and general laboratory procedures.
A long-chain acylcarnitine and GlyT2 inhibitor (IC50 = 340 nM); selective for GlyT2 over GlyT1 (IC50 = >10,000 nM); plasma levels are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality
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This kit provides Precellys 24 users with all of the necessary parts to properly maintain their instrument. EAch kit contains: 1 x Precellys 24 White Blocking Plate (2 mL) (Item No. 10422) 2 x Precellys 24 Vacuum Joint (toric joint) (Item No. 10011148) 1 x Precellys 24 Containment Seal (Item No. 10011149)] 1 x Precellys 24 Anti-Rotation Tubing Kit - (Item No. 10011162) [Bertin Catalog S000688-PR240-A.0; Previously SP03119-810-NC011.0]
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An analog of ceramide and a GPR119 agonist (EC50 = 12 µM); induces cell death in F-11 murine neuroblastoma and U-87 human astrocytoma cells at 100 µM; induces apoptosis in rapidly dividing cells and prevents teratoma formation in a neonatal mouse engraftment model of teratoma formation
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An essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism; the pantothenate kinase step of the coenzyme A biosynthetic pathway has been identified as a target for the development of antibacterial compounds
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An endogenous N-acyl amine; induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64% at 50 µM; inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with TRPV1 and RFP; reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice at 100 mg/kg
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Also available in 25 mg 50 mg 200 mg and bulk. Please contact Fisher for quotes. Aminopeptidase M (AMP) inhibition is of interest for several diseases such as highly vascularized cancer types. purity: 98%
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